A randomized controlled trial gave 37 patients with alcohol use disorder either psilocybin or a placebo and then examined their DNA methylation — chemical changes that regulate gene activity without altering DNA itself. Psilocybin produced significant changes in genes linked to serotonin signaling, immune response, and inflammation, pointing toward biological mechanisms behind its therapeutic effects.
(c) Nikola Tomašić

Psilocybin leaves measurable epigenetic marks in people with alcohol use disorder

MEDICAL XPRESS

A randomized controlled trial gave 37 patients with alcohol use disorder either psilocybin or a placebo and then examined their DNA methylation — chemical changes that regulate gene activity without altering DNA itself. Psilocybin produced significant changes in genes linked to serotonin signaling, immune response, and inflammation, pointing toward biological mechanisms behind its therapeutic effects.

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