A randomized controlled trial gave 37 patients with alcohol use disorder either psilocybin or a placebo and then examined their DNA methylation — chemical changes that regulate gene activity without altering DNA itself. Psilocybin produced significant changes in genes linked to serotonin signaling, immune response, and inflammation, pointing toward biological mechanisms behind its therapeutic effects.
(c) Nikola Tomašić

La psilocibina deja marcas epigenéticas medibles en personas con trastorno por alcohol

MEDICAL XPRESS

Un ensayo clínico aleatorizado publicado en Translational Psychiatry administró psilocibina o placebo a 37 pacientes con trastorno por uso de alcohol y luego analizó su metilación del ADN — cambios químicos que regulan la actividad génica sin alterar el ADN. La psilocibina produjo cambios significativos en genes relacionados con la señalización de serotonina, la respuesta inmune y la inflamación.

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