A randomized controlled trial gave 37 patients with alcohol use disorder either psilocybin or a placebo and then examined their DNA methylation — chemical changes that regulate gene activity without altering DNA itself. Psilocybin produced significant changes in genes linked to serotonin signaling, immune response, and inflammation, pointing toward biological mechanisms behind its therapeutic effects.
(c) Nikola Tomašić

La psilocybine laisse des traces épigénétiques mesurables chez des patients souffrant d’alcoolisme

MEDICAL XPRESS

Un essai contrôlé randomisé a administré de la psilocybine ou un placebo à 37 patients souffrant de troubles liés à l’alcool, avant d’analyser leur méthylation de l’ADN — des modifications chimiques qui régulent l’activité des gènes sans altérer la séquence d’ADN. La psilocybine a provoqué des changements significatifs dans des gènes liés à la signalisation de la sérotonine, à la réponse immunitaire et à l’inflammation.

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