A randomized controlled trial gave 37 patients with alcohol use disorder either psilocybin or a placebo and then examined their DNA methylation — chemical changes that regulate gene activity without altering DNA itself. Psilocybin produced significant changes in genes linked to serotonin signaling, immune response, and inflammation, pointing toward biological mechanisms behind its therapeutic effects.
(c) Nikola Tomašić

Psilocybin hinterlässt messbare epigenetische Spuren bei Menschen mit Alkoholproblemen

MEDICAL XPRESS

Eine in Translational Psychiatry veröffentlichte randomisierte kontrollierte Studie verabreichte 37 Patientinnen und Patienten mit Alkoholkonsumstörung Psilocybin oder ein Placebo und untersuchte anschliessend chemische Veränderungen, die die Genaktivität regulieren. Psilocybin verursachte signifikante Veränderungen in Genen der Serotoninsignalisierung, Immunantwort und Entzündungsregulation.

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